Dimethyl Sulfoxide
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100.0% | 78.13 | C2H6OS | 200mL
Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity[1] br/ Low endotoxin can be used in various biochemical experiments such as drug dissolution
Apexbio Technology LLC Ivacaftor (VX-770)(Synonyms: Kalydeco, VX-770, Ivacaftor, CFTR Potentiator VX-770, Ivacaftor VX-770), 10mM (in 1mL DMSO), CAS: 873054-44-5.
Ivacaftor (VX-770 CAS 873054-44-5) is an orally bioavailable small molecule potentiator targeting the cystic fibrosis transmembrane conductance regulator (CFTR) Ivacaftor enhances CFTR-mediated chloride ion transport especially in cells expressing G551D- or F508del-CFTR mutations In vitro studies demonstrated that Ivacaftor in combination with forskolin significantly increased CFTR-dependent chloride secretion (EC50 100 nM in G551D- 25 nM in F508del-expressing cells) Similarly Ivacaftor reduced ENaC-mediated sodium reabsorption and increased airway surface liquid volume in human cystic fibrosis bronchial epithelial cells Ivacaftor is utilized in research to investigate CFTR function restoration and associated ion transport processes
Apexbio Technology LLC Crenolanib (CP-868596)(Synonyms: CP-868596, Crenolanib besylate, AR-868596, PDGFR inhibitor CP-868596, PDGFR-beta inhibitor CP-868596), 10mM (in 1mL DMSO), CAS: 670220-88-9.
Crenolanib (CP-868596 CAS 670220-88-9) is a selective inhibitor targeting receptor tyrosine kinases PDGFR PDGFR and FLT3 exhibiting Kd values of 3 2 nM 2 1 nM and 0 74 nM respectively It notably suppresses the FLT3 autophosphorylation and proliferation mediated via PDGFR mutations that confer resistance to imatinib such as D842V (IC50 10 nM) but does not inhibit the V561D mutant Additionally crenolanib reduces kinase activity of the FIP1L1-PDGFRA fusion protein (IC50 1 nM) and proliferation in EOL-1 cells It serves as a research tool for kinase-driven malignancies particularly those resistant to other kinase inhibitors
Selleck Chemical LLC OSS_128167, 10mM (1mL in DMSO)
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.
Apexbio Technology LLC Calcitriol 32222-06-3 10mM (in 1mL DMSO)
Calcitriol the biologically active metabolite of vitamin D3 functions primarily through interaction with the intracellular vitamin D receptor (VDR) regulating transcription of genes involved in mineral homeostasis and immune responses It modulates cellular differentiation proliferation and adaptive immune functions via nuclear receptor-mediated mechanisms In vitro studies demonstrate that calcitriol dose-dependently inhibits lipopolysaccharide (LPS)-stimulated tumor necrosis factor-alpha (TNF- ) and interleukin-1 (IL-1 ) secretion from human peripheral blood mononuclear cells (PBMCs) Additionally animal models indicate that calcitriol administration decreases cytokine release associated with inflammatory stimuli through intracellular calcium-dependent signaling pathways Calcitriol is widely utilized in biomedical research concerning osteometabolic regulation immune modulation and cytokine signaling networks
Apexbio Technology LLC Rucaparib (AG-014699,PF-01367338) 459868-92-9 10mM (in 1mL DMSO)
Rucaparib (AG-014699 PF-01367338 CAS 459868-92-9) is a small molecule inhibitor targeting poly(ADP-ribose) polymerase (PARP) a nuclear enzyme activated by DNA damage and central to the base excision repair pathway By blocking PARP activity rucaparib impairs DNA repair especially in cells with pre-existing DNA repair deficiencies such as those induced by genotoxic stress In prostate cancer research rucaparib induces radiosensitization notably in PTEN-deficient cells expressing ETS fusion proteins through inhibition of non-homologous end joining (NHEJ) It is thus relevant in studies investigating DNA damage response pathways cancer biology and therapeutic radiosensitization strategies
Apexbio Technology LLC GW788388 452342-67-5 10mM (in 1mL DMSO)
GW788388 (CAS 452342-67-5) is a selective inhibitor targeting activin receptor-like kinase 5 (ALK5) the type I receptor for transforming growth factor-beta (TGF- ) It inhibits the kinase activity of ALK5 suppressing TGF- -mediated signaling cascades GW788388 demonstrates potent inhibition of ALK5 autophosphorylation with an IC50 of 18 nM leading to decreased Smad2 phosphorylation It also inhibits TGF- -induced epithelial-mesenchymal transition (EMT) cellular proliferation fibrosis and angiogenesis in various cell models such as NMuMG MDA-MB-231 RCC and U2OS In animal studies GW788388 ameliorates renal fibrosis in diabetic db/db mouse models highlighting its utility in investigating TGF- -driven pathophysiological processes
Sigma Aldrich Fine Chemicals Biosciences Promethazine sulfoxide Bri
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.for further information and support please go to the website of the issuing Pharmacopoeia.
Apexbio Technology LLC JSH-23 749886-87-1 10mM (in 1mL DMSO)
JSH-23 (CAS 749886-87-1) is a small-molecule inhibitor of NF- B transcriptional activity exhibiting an IC50 of approximately 7 1 M Mechanistically JSH-23 prevents NF- B-mediated gene transcription by reducing nuclear localization and DNA binding activity of the NF- B p65 subunit without interfering with I B degradation In LPS-stimulated RAW 264 7 macrophages JSH-23 decreases expression of pro-inflammatory mediators including IL-6 IL-1 COX-2 and TNF- and inhibits apoptotic chromatin condensation This compound serves as a research tool for studying NF- B signaling and related inflammatory processes
Apexbio Technology LLC Levosimendan 141505-33-1 10mM (in 1mL DMSO)
Levosimendan (CAS 141505-33-1) is a small molecule calcium sensitizer that exerts its pharmacological action by binding selectively and in a calcium-dependent manner to cardiac troponin C (cTnC) Through this interaction levosimendan facilitates cardiac muscle contraction without significantly increasing intracellular calcium concentrations Research indicates utility in heart failure treatment where improved myocardial contractility is therapeutically desirable Currently levosimendan is evaluated extensively in Phase 4 clinical studies to explore its efficacy and therapeutic profile
Apexbio Technology LLC GW441756 504433-23-2 10mM (in 1mL DMSO)
GW441756 (CAS 504433-23-2) is a small-molecule inhibitor targeting TrkA kinase and LRRK2 It inhibits TrkA kinase activity with an IC50 of 320 nM potentially modulating downstream signaling involved in cellular proliferation differentiation and apoptosis Selectivity studies indicated limited inhibitory effects on other kinases such as cRaf1 and CDK2 with respective IC50 values above 12 M and 7 M GW441756 induced dose-dependent anti-proliferative and pro-apoptotic effects in the human sarcoma cell line HTB114 It also inhibited LRRK2-mediated phosphorylation at Ser935 (IC50 2 2 M) without significant cytotoxicity (IC50 20 M) GW441756 serves as a research tool in oncology and neurobiology
Apexbio Technology LLC QNZ (EVP4593) 545380-34-5 10mM (in 1mL DMSO)
QNZ (EVP4593 CAS number 545380-34-5) is a quinazoline-derived small molecule inhibitor of the NF- B signaling pathway Originally identified using a luciferase reporter assay in human Jurkat T cells QNZ effectively suppresses PMA/PHA-induced NF- B transcriptional activation (IC50 11 nM) and TNF- production (IC50 7 nM) Additionally QNZ demonstrates anti-inflammatory properties reducing edema formation in a carrageenan-induced rat paw swelling model In Huntington s disease research QNZ improved motor performance in transgenic fly models without toxicity suggesting potential neuroprotective applications
Apexbio Technology LLC Ulipristal 159811-51-5 10mM (in 1mL DMSO)
Ulipristal is a selective progesterone receptor modulator (SPRM) exhibiting tissue-specific agonist and antagonist activities on progesterone-sensitive targets It functions through competitively binding to the progesterone receptor thereby modulating downstream cellular and physiological responses Ulipristal has been explored in biomedical research primarily for emergency contraception administered within 120 hours following unprotected intercourse Additionally ulipristal demonstrates potential utility in managing benign gynecological disorders such as uterine fibroids (leiomyomas) by mediating apoptosis in myomatous cells and controlling cellular proliferation In vitro studies indicate that ulipristal acetate inhibits progesterone-stimulated acrosome reactions and hyperactivation of human spermatozoa highlighting its potential receptor-mediated modulation of sperm functions
Apexbio Technology LLC SW033291 459147-39-8 10mM (in 1mL DMSO)
SW033291 (CAS 459147-39-8) is a small molecule inhibitor targeting the prostaglandin-degrading enzyme 15-PGDH It inhibits 15-PGDH activity non-competitively displaying potent inhibition with an IC50 of 1 5 nM and an apparent dissociation constant (Ki app) of approximately 0 1 nM Cellular assays in A549 cells demonstrate that SW033291 elevates prostaglandin E2 (PGE2) levels (EC50 75 nM) In vivo administration of SW033291 in mice significantly elevates tissue PGE2 concentrations stimulates hematopoietic cytokine expression expands hematopoietic stem and progenitor cell populations and promotes neutrophil expansion Thus SW033291 represents a research tool for studying PGE2-related pathways in tissue regeneration and hematopoiesis